Spider Splicer (Bioshock)
The fast and agile Spider Splicer can be a real pain to deal with during your stint in Rapture’s underwater vistas. The Spider Splicer forces you to think and react quickly, as it throws its hooks into you, or drops down from the ceiling and tears you up. Fighting more than one of these bastards at a time, or along with common Splicers, requires a fine balance of clever plasmid use in combination with superior firepower and true aim. They certainly live up to their name with their creepy crawling nature.
Fireman (Bioshock Infinite)
The Fireman is one of Infinite’s heavy enemies, but unlike actual firemen, these guys aren’t putting out any fires. Bombarding Booker with a barrage of explosive fireballs, they are equally dangerous far away as they are up-close, with a searing hot area-of-effect fireball attack. They look something like if a Big Daddy got it on with a stove and had a baby, and is equally dangerous. They like to show up along the more basic enemies, upping the difficulty of the fight considerably.
Thuggish Splicer (Bioshock)
The most basic enemy in all of Bioshock is the Thuggish Splicer. They make the list, not so much for their difficulty in battle, but because of the eerie atmosphere they brought to the original Bioshock experience. Whenever they’re around - you can hear their manic ranting, which escalates into hysteric death threats when they engage you. There’s simply something really unsettling about observing these mutated citizens of Rapture, both merely a shadow of their former self, still lurking in the desolate city.
Handyman (Bioshock Infinite)
Bettermen Autobodies proudly presents: The Handyman! This twisted creature fuses flesh and steel into one of the most relentless and threatening enemies that the series has to offer. Incredibly strong, while fast and surprisingly agile, the Handyman will come at you with unrelenting ferocity, screaming and grunting from the top of its lungs. Even though it has a glaring weak spot on its chest, you’ll need to use your vigor’s and think on your feet in order to get a clear shot. The Handyman is disturbingly tormented, and I almost felt sorry for them each time I finally brought one down… well, as sorry as you can feel for a 12-foot monstrosity that is attempting to brutally murder you.
Bouncer Big Daddy (Bioshock)
The top spot is reserved for the most iconic of Bioshock enemies: The Bouncer Big Daddy. Since first appearing in the striking trailer for the original Bioshock, the drill wielding Big Daddy has become the series’ unofficial mascot. Let’s not forget that Big Daddies weren’t necessarily an enemy. They would not attack (except for in a few scripted fights) unless provoked, and were often best avoided in the early stages of the game until you had beefed up your arsenal of guns and plasmids. Half of the enjoyment of fighting a Big Daddy came from preparing for the fight. As they roam around an area you could set traps, stock up on ammo, eve, and health kits, before laying into the heavily armored beast. Friend or foe the Big Daddy stands as one of the most iconic enemy characters, not only in the Bioshock series, but in the current generation of games.
There you have it, our picks for the best Bioshock enemies. There are a bunch of cool ones that didn't make the list, like the other various Splicers and Big Daddies. There are some enemies in the series that aren't all that great either, such as the messy Big Sister, but on the whole the Bioshock series offers some of the most unique and colorful enemies of any shooter in recent years.